Frances Alberta McKinney

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      Sex: F

AKA: Francis

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Individual Information

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     Birth Date: 31 Dec 1915 - Hardintown, Indiana
    Christening: 
          Death: 15 Aug 1929 - Elizabethtown, Whitewater Twp., Hamilton, Ohio
         Burial: 17 Aug 1929 - Greendale Cemetery, Lawrenceburg, Dearborn, Indiana, USA
 Cause of Death: Hereditary spastic paraplegia, duration 6 years, contributary cause edema of the lungs, duration 3 days

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Parents

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         Father: William Holman McKinney
         Mother: Katie Priscilla Hayes

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Notes

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General:

Per death certificate:
Frances Alberta Mckinney, a single white female was born Dec. 31, 1915 in Hardintown, Indiana. She died on August 15, 1929, at the age of 13 years, 7 months, and 16 days. Her last residence was Whitewater Twp., Hamilton, Ohio. Her father was Wm McKinney of Indiana, her mother Kate P. Hayes of Elizabethtown, Ohio. Informant was Mrs Wm McKinney of Elizabethtown, Ohio (probably her mother).
Cause of death, as certified by A. M. Mueller, M. D. of Lawrenceburg, Indiana on Aug 16, 1929 was hereditary spastic paraplegia, duration 6 years. Contributary cause was edema of the lungs, duration 3 days.
Untertaker was Sitch Bros of Lawrenceburg, Indiana. The body was embalmed (lic no 389B). Place of burial was Greendale, Indiana on Aug 17, 1929.
GSU film number: 1991908 Digital GS number: 4022273 Image number: 2650 Reference number: fn 52622

Per Findagrave.com
Birth: Dec. 31, 1915 Lawrenceburg, Dearborn County, Indiana, USA
Death: Aug. 15, 1929 Lawrenceburg, Dearborn County, Indiana, USA
k/o W & Kate P McKinney
burial permit #5610
Burial: Greendale Cemetery Lawrenceburg, Dearborn County, Indiana, USA, Plot: I-55
Created by: dhintx Record added: Apr 18, 2011
Find A Grave Memorial# 68593542

Medical:

Hereditary spastic paraplegia, autosomal dominant: A degenerative disorder of nerves with progressive spasticity of the legs. Abbreviated as AD-HSP.

Spasticity is a state of increased muscle tone. Paraplegia refers to the legs (quadriplegia refers to both the arms and legs). In hereditary spastic paraplegia there is an insidiously progressive condition characterized by weakness beginning in the feet and lower legs. There is stiffness of the legs in walking due to the spasticity.

Autosomal dominant hereditary spastic paraplegia can result from changes in a number of different genes. Each gene is autosomal (on an nonsex chromosome) and dominant (capable of causing the disease by itself).

Among the 4 genes causing AD-HSP found through 1999, one that is on chromosome 2 accounts for 40-50% of all families with AD-HSP. Researchers have identified a gene that is responsible for this most frequent form of AD-HSP. They named the gene "spastin" (for spasticity). Spastin appears to code for a critically important enzyme (in technical terms, an ATPase involved in the assembly or function of nuclear protein complexes). (Reference: Hazan J et al. Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia. Nature Genetics 23: 296 - 303, 1999.)